CATH Domain 2ishA00

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1240	Zincin-like
	3.90.1240.10	Metalloproteases ("zincins"), catalytic domain like

Superfamily	Metalloproteases ("zincins"), catalytic domain like
Functional Family	Botulinum neurotoxin type A

3.4.24.69

Bontoxilysin.

based on mapping to UniProt Q7B8V4

Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.

-!- Belongs to peptidase family M27.

Q7B8V4_CLOBO

Clostridium botulinum

BoNT/A

PDB	2ISH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons. Burnett, J.C., Ruthel, G., Stegmann, C.M., Panchal, R.G., Nguyen, T.L., Hermone, A.R., Stafford, R.G., Lane, D.J., Kenny, T.A., McGrath, C.F., Wipf, P., Stahl, A.M., Schmidt, J.J., Gussio, R., Brunger, A.T., Bavari, S. J.Biol.Chem.