CATH Domain 2iq1A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.40	Phosphatase 2c; domain 1
	3.60.40.10	PPM-type phosphatase domain

Domain Context

CATH Clusters

Superfamily	PPM-type phosphatase domain
Functional Family	Protein phosphatase 1K, mitochondrial

Enzyme Information

3.1.3.16

Protein-serine/threonine phosphatase.

based on mapping to UniProt Q8N3J5

[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.

-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

Q8N3J5

PPM1K_HUMAN

Homo sapiens

Protein phosphatase 1K, mitochondrial

PDB Structure

PDB	2IQ1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural genomics of protein phosphatases Almo, S.C., Bonanno, J.B., Sauder, J.M., Emtage, S., Dilorenzo, T.P., Malashkevich, V., Wasserman, S.R., Swaminathan, S., Eswaramoorthy, S., Agarwal, R., Kumaran, D., Madegowda, M., Ragumani, S., Patskovsky, Y., Alvarado, J., Ramagopal, U.A., Faber-Barata, J., Chance, M.R., Sali, A., Fiser, A., Zhang, Z.Y., Lawrence, D.S., Burley, S.K. J.STRUCT.FUNCT.GENOM.