CATH Domain 2in6A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Wee1-like kinase 2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P30291

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P30291

WEE1_HUMAN

Homo sapiens

Wee1-like protein kinase

PDB Structure

PDB	2IN6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Smaill, J.B., Baker, E.N., Booth, R.J., Bridges, A.J., Dickson, J.M., Dobrusin, E.M., Ivanovic, I., Kraker, A.J., Lee, H.H., Lunney, E.A., Ortwine, D.F., Palmer, B.D., Quin, J., Squire, C.J., Thompson, A.M., Denny, W.A. Eur.J.Med.Chem.