CATH Domain 2ihuB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1220	TPP-binding domain

Domain Context

CATH Clusters

Superfamily	TPP-binding domain
Functional Family	N(2)-(2-carboxyethyl)arginine synthase

Enzyme Information

2.5.1.66

N(2)-(2-carboxyethyl)arginine synthase.

based on mapping to UniProt Q9LCV9

D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L- arginine + phosphate.

-!- Requires thiamine diphosphate and catalyzes the first step in the clavulanic-acid biosynthesis pathway. -!- The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.

UniProtKB Entries (1)

Q9LCV9

CEAS_STRCL

Streptomyces clavuligerus

N(2)-(2-carboxyethyl)arginine synthase

PDB Structure

PDB	2IHU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase. Caines, M.E., Sorensen, J.L., Schofield, C.J. Biochem.Biophys.Res.Commun.