CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.70 | Cathepsin D, subunit A; domain 1 |
|
2.40.70.10 | Acid Proteases |
Domain Context
CATH Clusters
| Superfamily | Acid Proteases |
| Functional Family | Plasmepsin-2 |
Enzyme Information
| 3.4.23.39 |
Plasmepsin II.
based on mapping to UniProt Q17SC2
Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves small molecules substrates such as Ala-Leu-Glu-Arg-Thr-Phe-|-Phe(NO(2))-Ser-Phe-Pro-Thr.
-!- Inhibited by pepstatin. -!- Belongs to peptidase family A1.
|
UniProtKB Entries (1)
| Q17SC2 |
Q17SC2_PLAFA
Plasmodium falciparum
Plasmepsin 2
|
PDB Structure
| PDB | 2IGY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV.
Chemmedchem
|
