CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.470 | D-amino Acid Aminotransferase; Chain A, domain 1 |
|
3.30.470.160 | Inositol polyphosphate kinase |
Domain Context
CATH Clusters
| Superfamily | Inositol polyphosphate kinase |
| Functional Family | Inositol polyphosphate multikinase |
Enzyme Information
| 2.7.1.151 |
Inositol-polyphosphate multikinase.
based on mapping to UniProt P07250
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
-!- This enzyme also phosphorylates Ins(1,4,5)P(3) to Ins(1,3,4,5)P(4), Ins(1,3,4,5)P(4) to Ins(1,3,4,5,6)P(5), and Ins(1,3,4,5,6)P(4) to Ins(PP)P(4), isomer unknown. -!- The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P(4) and Ins(1,2,3,4,6)P(5) at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP(6)), respectively. -!- Yeast produces InsP(6) from Ins(1,4,5)P(3) by the actions of this enzyme and EC 2.7.1.158.
|
UniProtKB Entries (1)
| P07250 |
IPMK_YEAST
Saccharomyces cerevisiae S288C
Inositol polyphosphate multikinase
|
PDB Structure
| PDB | 2IEW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity.
J.Biol.Chem.
|
