CATH Domain 2idoA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family	DNA polymerase III subunit epsilon

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt P03007

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (2)

P03007	DPO3E_ECOLI Escherichia coli K-12 DNA polymerase III subunit epsilon
Q71T70	Q71T70_BPP1 Escherichia virus P1 Hot

PDB Structure

PDB	2IDO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of the Escherichia coli DNA polymerase III epsilon-HOT proofreading complex. Kirby, T.W., Harvey, S., DeRose, E.F., Chalov, S., Chikova, A.K., Perrino, F.W., Schaaper, R.M., London, R.E., Pedersen, L.C. J.Biol.Chem.