CATH Domain 2ibiA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Ubiquitin carboxyl-terminal hydrolase 2

Enzyme Information

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt O75604

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

P0CG48

UBC_HUMAN

Homo sapiens

Polyubiquitin-C

PDB Structure

PDB	2IBI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Covalent Ubiquitin-USP2 Complex Avvakumov, G.V., Walker, J.R., Bernstein, G., Xue, S., Finerty Jr., P.J., MacKenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S. To be Published