CATH Domain 2i72A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family	Beta-lactamase

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P00811

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P00811

AMPC_ECOLI

Escherichia coli K-12

Beta-lactamase

PDB Structure

PDB	2I72
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy Venturelli, A., Tondi, D., Cancian, L., Morandi, F., Cannazza, G., Segatore, B., Prati, F., Amicosante, G., Shoichet, B.K., Costi, M.P. J.Med.Chem.