CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.10490 | Glucose-6-phosphate isomerase like protein; domain 1 |
Domain Context
CATH Clusters
| Superfamily | Glucose-6-phosphate isomerase like protein; domain 1 |
| Functional Family | Phosphoheptose isomerase |
Enzyme Information
| 5.3.1.28 |
D-sedoheptulose 7-phosphate isomerase.
based on mapping to UniProt P63224
D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.
-!- In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core. -!- In Gram-positive bacteria the enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein.
|
UniProtKB Entries (1)
| P63224 |
GMHA_ECOLI
Escherichia coli K-12
Phosphoheptose isomerase
|
PDB Structure
| PDB | 2I22 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants
J.Biol.Chem.
|