CATH Domain 2hwoA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P00523

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00523

SRC_CHICK

Gallus gallus

Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB	2HWO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Blair, J.A., Rauh, D., Kung, C., Yun, C.H., Fan, Q.W., Rode, H., Zhang, C., Eck, M.J., Weiss, W.A., Shokat, K.M. Nat.Chem.Biol.