CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.20 |
Domain Context
CATH Clusters
| Superfamily | 2.60.120.20 |
| Functional Family | Genome polyprotein |
Enzyme Information
| 3.4.22.29 |
Picornain 2A.
based on mapping to UniProt P23008
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein.
-!- From entero- and rhinoviruses. -!- Smaller than the homologous virus picornain 3C. -!- Belongs to peptidase family C3.
|
| 3.6.1.15 |
Nucleoside-triphosphate phosphatase.
based on mapping to UniProt P23008
NTP + H(2)O = NDP + phosphate.
-!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
|
| 2.7.7.48 |
RNA-directed RNA polymerase.
based on mapping to UniProt P23008
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
|
| 3.4.22.28 |
Picornain 3C.
based on mapping to UniProt P23008
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
-!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
|
UniProtKB Entries (1)
| P23008 |
POLG_HRV1A
Human rhinovirus 1A
Genome polyprotein
|
PDB Structure
| PDB | 2HWE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Homo |
| Primary Citation |
A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.
J.Mol.Biol.
|