CATH Domain 2hw5A02

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.12	Lyase 2-enoyl-coa Hydratase; Chain A, domain 2
	1.10.12.10	Lyase 2-enoyl-coa Hydratase, Chain A, domain 2

Superfamily	Lyase 2-enoyl-coa Hydratase, Chain A, domain 2
Functional Family	Probable enoyl-CoA hydratase, mitochondrial

4.2.1.17

Enoyl-CoA hydratase.

based on mapping to UniProt P30084

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.

-!- Acts in the reverse direction. -!- With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).

ECHM_HUMAN

Homo sapiens

Enoyl-CoA hydratase, mitochondrial

PDB	2HW5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1 Turnbull, A.P., Salah, E., Niesen, F., Debreczeni, J., Ugochukwu, E., Pike, A.C.W., Kavanagh, K., Gileadi, O., Gorrec, F., Umeano, C., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Oppermann, U. To be Published