CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Serine protease 37

Enzyme Information

3.4.21.39
Chymase.
based on mapping to UniProt P23946
Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.
-!- In mast cell granules. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P23946
CMA1_HUMAN
Homo sapiens
Chymase

PDB Structure

PDB 2HVX
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
Greco, M.N., Hawkins, M.J., Powell, E.T., Almond, H.R., de Garavilla, L., Hall, J., Minor, L.K., Wang, Y., Corcoran, T.W., Di Cera, E., Cantwell, A.M., Savvides, S.N., Damiano, B.P., Maryanoff, B.E.
J.Med.Chem.