CATH Classification

Domain Context

CATH Clusters

Superfamily Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Functional Family Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P06213
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06213
INSR_HUMAN
Homo sapiens
Insulin receptor

PDB Structure

PDB 2HR7
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.
Lou, M., Garrett, T.P., McKern, N.M., Hoyne, P.A., Epa, V.C., Bentley, J.D., Lovrecz, G.O., Cosgrove, L.J., Frenkel, M.J., Ward, C.W.
Proc.Natl.Acad.Sci.Usa