CATH Classification
Domain Context
CATH Clusters
| Superfamily | Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 |
| Functional Family | Tyrosine-protein kinase receptor |
Enzyme Information
| 2.7.10.1 |
Receptor protein-tyrosine kinase.
based on mapping to UniProt P06213
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.
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UniProtKB Entries (1)
| P06213 |
INSR_HUMAN
Homo sapiens
Insulin receptor
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PDB Structure
| PDB | 2HR7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Cricetulus |
| Primary Citation |
The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.
Proc.Natl.Acad.Sci.Usa
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