CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.70 | Distorted Sandwich |
|
2.70.40 | Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A |
|
2.70.40.10 | Deoxyuridine triphosphatase (dUTPase) |
Domain Context
CATH Clusters
| Superfamily | 2.70.40.10 |
| Functional Family | dUTP diphosphatase |
Enzyme Information
| 3.6.1.23 |
dUTP diphosphatase.
based on mapping to UniProt P06968
dUTP + H(2)O = dUMP + diphosphate.
|
UniProtKB Entries (1)
| P06968 |
DUT_ECOLI
Escherichia coli K-12
Deoxyuridine 5'-triphosphate nucleotidohydrolase
|
PDB Structure
| PDB | 2HR6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
Proteins
|
