CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00735
THRB_BOVIN
Bos taurus
Prothrombin
P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 2HPP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin.
Arni, R.K., Padmanabhan, K., Padmanabhan, K.P., Wu, T.P., Tulinsky, A.
Biochemistry