CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.10 | Thrombin, subunit H | |
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
Superfamily | Trypsin-like serine proteases |
Functional Family | Prothrombin |
Enzyme Information
3.4.21.5 |
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.
|
UniProtKB Entries (2)
P00735 |
THRB_BOVIN
Bos taurus
Prothrombin
|
P00734 |
THRB_HUMAN
Homo sapiens
Prothrombin
|
PDB Structure
PDB | 2HPP |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin.
Biochemistry
|