CATH Domain 2higA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.460	Phosphofructokinase domain

Domain Context

CATH Clusters

Superfamily	Phosphofructokinase domain
Functional Family

Enzyme Information

2.7.1.11

6-phosphofructokinase.

based on mapping to UniProt O15648

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.

-!- D-tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors. -!- UTP, CTP and ITP can act as donors. -!- Not identical with EC 2.7.1.105.

UniProtKB Entries (1)

O15648

PFKA_TRYBB

Trypanosoma brucei brucei

ATP-dependent 6-phosphofructokinase

PDB Structure

PDB	2HIG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The First Crystal Structure of Phosphofructokinase from a Eukaryote: Trypanosoma brucei. Martinez-Oyanedel, J., McNae, I.W., Nowicki, M.W., Keillor, J.W., Michels, P.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D. J.Mol.Biol.