CATH Domain 2hhnA00

Superfamily	Cysteine proteinases
Functional Family	Cathepsin S

3.4.22.27

Cathepsin S.

based on mapping to UniProt P25774

Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.

-!- A lysosomal cysteine endopeptidase that is unusual among such enzymes for its stability to neutral pH. -!- Belongs to peptidase family C1.

CATS_HUMAN

Homo sapiens

Cathepsin S

PDB	2HHN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers Tully, D.C., Liu, H., Chatterjee, A.K., Alper, P.B., Epple, R., Williams, J.A., Roberts, M.J., Woodmansee, D.H., Masick, B.T., Tumanut, C., Li, J., Spraggon, G., Hornsby, M., Chang, J., Tuntland, T., Hollenbeck, T., Gordon, P., Harris, J.L., Karanewsky, D.S. Bioorg.Med.Chem.Lett.