CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P54763
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P54763
EPHB2_MOUSE
Mus musculus
Ephrin type-B receptor 2

PDB Structure

PDB 2HEN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases
Wiesner, S., Wybenga-Groot, L.E., Warner, N., Lin, H., Pawson, T., Forman-Kay, J.D., Sicheri, F.
EMBO J.