CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) |
|
1.20.120.550 | Membrane associated eicosanoid/glutathione metabolism-like domain |
Domain Context
CATH Clusters
| Superfamily | Membrane associated eicosanoid/glutathione metabolism-like domain |
| Functional Family | Microsomal glutathione S-transferase 1 |
Enzyme Information
| 2.5.1.18 |
Glutathione transferase.
based on mapping to UniProt P08011
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
|
UniProtKB Entries (1)
| P08011 |
MGST1_RAT
Rattus norvegicus
Microsomal glutathione S-transferase 1
|
PDB Structure
| PDB | 2H8A |
| External Links | |
| Method | ELECTRON CRYSTALLOGRAPHY |
| Organism | |
| Primary Citation |
Structural basis for detoxification and oxidative stress protection in membranes.
J.Mol.Biol.
|
