CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.700 | Flavocytochrome C3; Chain A, domain 1 |
|
3.90.700.10 | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain |
| Functional Family | Mitochondrial succinate dehydrogenase flavoprotein subunit |
Enzyme Information
| 1.3.5.1 |
Succinate dehydrogenase (quinone).
based on mapping to UniProt Q9YHT1
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.
|
UniProtKB Entries (1)
| Q9YHT1 |
SDHA_CHICK
Gallus gallus
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
|
PDB Structure
| PDB | 2H89 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the
Biochim.Biophys.Acta
|
