CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.66 | Viral Topoisomerase I |
|
3.30.66.10 | DNA topoisomerase I domain |
Domain Context
CATH Clusters
| Superfamily | DNA topoisomerase I domain |
| Functional Family |
Enzyme Information
| 5.6.2.2 |
DNA topoisomerase.
based on mapping to UniProt P32989
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.
|
UniProtKB Entries (1)
| P32989 |
TOP1_VAR67
Variola virus human/India/Ind3/1967
DNA topoisomerase 1
|
PDB Structure
| PDB | 2H7F |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis for specificity in the poxvirus topoisomerase.
Mol.Cell
|
