CATH Domain 2h5gA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.309	Aldehyde Dehydrogenase; Chain A, domain 2
	3.40.309.10	Aldehyde Dehydrogenase; Chain A, domain 2

Domain Context

CATH Clusters

Superfamily	Aldehyde Dehydrogenase; Chain A, domain 2
Functional Family	Delta-1-pyrroline-5-carboxylate synthase

Enzyme Information

2.7.2.11	Glutamate 5-kinase. based on mapping to UniProt P54886 ATP + L-glutamate = ADP + L-glutamate 5-phosphate. -!- The product rapidly cyclizes to 5-oxoproline and phosphate.
1.2.1.41	Glutamate-5-semialdehyde dehydrogenase. based on mapping to UniProt P54886 L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH.

UniProtKB Entries (1)

P5CS_HUMAN

Homo sapiens

Delta-1-pyrroline-5-carboxylate synthase

PDB Structure

PDB	2H5G
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of human pyrroline-5-carboxylate synthetase Papagrigoriou, E., Shafqat, N., Turnbull, A.P., Berridge, G., Hozjan, V., Kavanagh, K., Gileadi, O., Smee, C., Bray, J., Gorrec, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oppermann, U. To be published