CATH Domain 2gz8A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Replicase polyprotein 1a

Enzyme Information

UniProtKB Entries (1)

Q692E5_CVHSA

SARS coronavirus TJF

Orf1a polyprotein

PDB Structure

PDB	2GZ8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease Lu, I.L., Mahindroo, N., Liang, P.H., Peng, Y.H., Kuo, C.J., Tsai, K.C., Hsieh, H.P., Chao, Y.S., Wu, S.Y. J.Med.Chem.