CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family

Enzyme Information

3.5.4.37
Double-stranded RNA adenine deaminase.
based on mapping to UniProt P55265
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3).
-!- This eukaryotic enzyme is involved in RNA editing. -!- It destabilizes double-stranded RNA through conversion of adenosine to inosine. -!- Inositol hexakisphosphate is required for activity.

UniProtKB Entries (1)

P55265
DSRAD_HUMAN
Homo sapiens
Double-stranded RNA-specific adenosine deaminase

PDB Structure

PDB 2GXB
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A Left-Handed RNA Double Helix Bound by the Zalpha Domain of the RNA-Editing Enzyme ADAR1.
Placido, D., Brown, B.A., Lowenhaupt, K., Rich, A., Athanasiadis, A.
Structure
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