CATH Classification

Domain Context

CATH Clusters

Superfamily Toxin ADP-ribosyltransferase; Chain A, domain 1
Functional Family

Enzyme Information

2.4.2.31
NAD(+)--protein-arginine ADP-ribosyltransferase.
based on mapping to UniProt P21454
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)- protein-L-arginine.
-!- Arginine residues in proteins act as acceptors. -!- Free arginine, agmatine ((4-aminobutyl)guanidine), arginine methyl ester and guanidine can also do so. -!- The enzyme from some, but not all, species can also use NADP(+) as acceptor (giving rise to N(omega)-((2'-phospho-ADP)-D-ribosyl)- protein-L-arginine as the product), but more slowly. -!- Catalyzes the NAD(+)-dependent activation of EC 4.6.1.1. -!- Some bacterial enterotoxins possess similar enzymatic activities (cf. EC 2.4.2.36).

UniProtKB Entries (1)

P21454
SPVB_SALTM
Salmonella enterica subsp. enterica serovar Typhimurium
Mono(ADP-ribosyl)transferase SpvB

PDB Structure

PDB 2GWL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A steric antagonism of actin polymerization by a salmonella virulence protein.
Margarit, S.M., Davidson, W., Frego, L., Stebbins, C.E.
Structure