CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.1230 | Nucleotide cyclase |
Domain Context
CATH Clusters
| Superfamily | Nucleotide cyclase |
| Functional Family | Adenylate cyclase |
Enzyme Information
| 4.6.1.1 |
Adenylate cyclase.
based on mapping to UniProt P30803
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.
|
UniProtKB Entries (3)
| P26769 |
ADCY2_RAT
Rattus norvegicus
Adenylate cyclase type 2
|
| P30803 |
ADCY5_CANLF
Canis lupus familiaris
Adenylate cyclase type 5
|
| P04896 |
GNAS2_BOVIN
Bos taurus
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
|
PDB Structure
| PDB | 2GVD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Broad specificity of Mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors.
Mol.Pharmacol.
|