CATH Domain 2gv7A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Transmembrane serine protease 7

Enzyme Information

3.4.21.109

Matriptase.

based on mapping to UniProt Q9Y5Y6

Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.

-!- This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis. -!- Can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain form at an Arg residue to give active alpha- and beta-HGF, but it does not activate plasminogen, which shares high homology with HGF. -!- Can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade. -!- Belongs to peptidase family S1A.

UniProtKB Entries (1)

Q9Y5Y6

ST14_HUMAN

Homo sapiens

Suppressor of tumorigenicity 14 protein

PDB Structure

PDB	2GV7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Secondary Amides of Sulfonylated 3-Amidinophenylalanine. New Potent and Selective Inhibitors of Matriptase. Steinmetzer, T., Schweinitz, A., Sturzebecher, A., Donnecke, D., Uhland, K., Schuster, O., Steinmetzer, P., Muller, F., Friedrich, R., Than, M.E., Bode, W., Sturzebecher, J. J.Med.Chem.