CATH Domain 2gu8A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	cAMP-dependent protein kinase catalytic subunit

Enzyme Information

2.7.11.11

cAMP-dependent protein kinase.

based on mapping to UniProt P17612

ATP + a protein = ADP + a phosphoprotein.

-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P17612

KAPCA_HUMAN

Homo sapiens

CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB	2GU8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies Lin, X., Murray, J.M., Rico, A.C., Wang, M.X., Chu, D.T., Zhou, Y., Del Rosario, M., Kaufman, S., Ma, S., Fang, E., Crawford, K., Jefferson, A.B. Bioorg.Med.Chem.Lett.