CATH Domain 2gtnA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Mitogen-activated protein kinase 14

Enzyme Information

2.7.11.24

Mitogen-activated protein kinase.

based on mapping to UniProt P47811

ATP + a protein = ADP + a phosphoprotein.

-!- Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation. -!- Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline. -!- A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY). -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P47811

MK14_MOUSE

Mus musculus

Mitogen-activated protein kinase 14

PDB Structure

PDB	2GTN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production. Sabat, M., Vanrens, J.C., Clark, M.P., Brugel, T.A., Maier, J., Bookland, R.G., Laufersweiler, M.J., Laughlin, S.K., Golebiowski, A., De, B., Hsieh, L.C., Walter, R.L., Mekel, M.J., Janusz, M.J. Bioorg.Med.Chem.Lett.