CATH Domain 2gf2D02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	3-hydroxyisobutyrate dehydrogenase

Enzyme Information

1.1.1.31

3-hydroxyisobutyrate dehydrogenase.

based on mapping to UniProt P31937

3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.

UniProtKB Entries (1)

3HIDH_HUMAN

Homo sapiens

3-hydroxyisobutyrate dehydrogenase, mitochondrial

PDB Structure

PDB	2GF2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of human hydroxyisobutyrate dehydrogenase Papagrigoriou, E., Salah, E., Turnbull, A.P., Smee, C., Burgess, N., Gileadi, O., von Delft, F., Gorrec, F., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Edwards, A.M., Oppermann, U. To be Published