CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family |
Enzyme Information
| 1.1.1.141 |
15-hydroxyprostaglandin dehydrogenase (NAD(+)).
based on mapping to UniProt P15428
(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH.
-!- Acts on prostaglandins E(2), F(2-alpha) and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.196 and EC 1.1.1.197).
|
UniProtKB Entries (1)
| P15428 |
PGDH_HUMAN
Homo sapiens
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
|
PDB Structure
| PDB | 2GDZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships.
Plos One
|
