CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.460 | Beta Polymerase; domain 2 |
|
3.30.460.60 | Poxvirus poly(A) polymerase, nucleotidyltransferase domain |
Domain Context
CATH Clusters
| Superfamily | Poxvirus poly(A) polymerase, nucleotidyltransferase domain |
| Functional Family |
Enzyme Information
| 2.7.7.19 |
Polynucleotide adenylyltransferase.
based on mapping to UniProt P23371
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.
|
UniProtKB Entries (2)
| Q1PIV4 |
Q1PIV4_9POXV
Vaccinia virus
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
|
| P23371 |
PAP1_VACCW
Vaccinia virus WR
Poly(A) polymerase catalytic subunit
|
PDB Structure
| PDB | 2GAF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of the vaccinia virus polyadenylate polymerase heterodimer: insights into ATP selectivity and processivity.
Mol.Cell
|