CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1660 | CofE-like fold |
|
3.90.1660.10 | CofE-like domain |
Domain Context
CATH Clusters
| Superfamily | CofE-like domain |
| Functional Family |
Enzyme Information
| 6.3.2.34 |
Coenzyme F420-1:gamma-L-glutamate ligase.
based on mapping to UniProt O28028
GTP + coenzyme F420-1 + L-glutamate = GDP + phosphate + coenzyme gamma- F420-2.
-!- This protein catalyzes the successive addition of two glutamate residues to cofactor F420 by two distinct and independent reactions. -!- In the first reaction (EC 6.3.2.31) the enzyme attaches a glutamate via its alpha-amine group to F420-0. -!- In the second reaction, which is described here, the enzyme catalyzes the addition of a second L-glutamate residue to the gamma-carboxyl of the first glutamate.
|
| 6.3.2.31 |
Coenzyme F420-0:L-glutamate ligase.
based on mapping to UniProt O28028
GTP + coenzyme F420-0 + L-glutamate = GDP + phosphate + coenzyme F420-1.
-!- This protein catalyzes the successive addition of two glutamate residues to cofactor F420 by two distinct and independent reactions. -!- In the reaction described here the enzyme attaches a glutamate via its alpha-amine group to F420-0. -!- In the second reaction (EC 6.3.2.34) it catalyzes the addition of a second L-glutamate residue to the gamma-carboxyl of the first glutamate.
|
UniProtKB Entries (1)
| O28028 |
COFE_ARCFU
Archaeoglobus fulgidus DSM 4304
Coenzyme F420:L-glutamate ligase
|
PDB Structure
| PDB | 2G9I |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of an amide bond forming F(420):gamma-glutamyl ligase from Archaeoglobus fulgidus -- a member of a new family of non-ribosomal peptide synthases.
J.Mol.Biol.
|
