CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.720 | Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1 |
|
1.10.720.60 |
Domain Context
CATH Clusters
| Superfamily | 1.10.720.60 |
| Functional Family | Enolase-phosphatase E1 |
Enzyme Information
| 3.1.3.77 |
Acireductone synthase.
based on mapping to UniProt P32626
5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O = 1,2-dihydroxy-5- (methylthio)pent-1-en-3-one + phosphate.
-!- This bifunctional enzyme first enolizes the substrate to form the intermediate 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate, which is then dephosphorylated to form the acireductone 1,2- dihydroxy-5-(methylsulfanyl)pent-1-en-3-one. -!- The acireductone represents a branch point in the methione salvage pathway as it is used in the formation of formate, CO and 3-(methylsulfanyl)propanoate by EC 1.13.11.53 and of formate and 4-(methylsulfanyl)-2-oxobutanoate either by a spontaneous reaction under aerobic conditions or by EC 1.13.11.54.
|
UniProtKB Entries (1)
| P32626 |
ENOPH_YEAST
Saccharomyces cerevisiae S288C
Enolase-phosphatase E1
|
PDB Structure
| PDB | 2G80 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of UTR4 protein (Unknown transcript 4 protein) (yel038w) from Saccharomyces cerevisiae at 2.28 A resolution
To be published
|
