CATH Classification

Domain Context

CATH Clusters

Superfamily Metalloproteases ("zincins"), catalytic domain like
Functional Family Botulinum neurotoxin type A

Enzyme Information

3.4.24.69
Bontoxilysin.
based on mapping to UniProt Q45894
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.

UniProtKB Entries (1)

Q45894
BXA2_CLOBJ
Clostridium botulinum A2 str. Kyoto
Botulinum neurotoxin type A2

PDB Structure

PDB 2G7Q
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate.
Fu, Z., Chen, S., Baldwin, M.R., Boldt, G.E., Crawford, A., Janda, K.D., Barbieri, J.T., Kim, J.J.
Biochemistry