CATH Domain 2g4oA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.718	Isopropylmalate Dehydrogenase
	3.40.718.10	Isopropylmalate Dehydrogenase

Domain Context

CATH Clusters

Superfamily	Isopropylmalate Dehydrogenase
Functional Family	3-isopropylmalate dehydrogenase

Enzyme Information

1.1.1.85

3-isopropylmalate dehydrogenase.

based on mapping to UniProt P9WKK9

(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO(2) + NADH.

UniProtKB Entries (1)

LEU3_MYCTU

Mycobacterium tuberculosis H37Rv

3-isopropylmalate dehydrogenase

PDB Structure

PDB	2G4O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Mueller-Dieckmann, C., Panjikar, S., Schmidt, A., Mueller, S., Kuper, J., Geerlof, A., Wilmanns, M., Singh, R.K., Tucker, P.A., Weiss, M.S. Acta Crystallogr.,Sect.D