CATH Domain 2g1nA02

Superfamily	Acid Proteases
Functional Family	Renin

3.4.23.15

Renin.

based on mapping to UniProt P00797

Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

-!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.15 and EC 3.4.99.19.

RENI_HUMAN

Homo sapiens

Renin

PDB	2G1N
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Ketopiperazine-based renin inhibitors: Optimization of the "C" ring Holsworth, D.D., Cai, C., Cheng, X.M., Cody, W.L., Downing, D.M., Erasga, N., Lee, C., Powell, N.A., Ednunds, J.J., Stier, M., Jalaie, M., Zhang, E., McConnell, P., Ryan, M.J., Bryant, J., Li, T., Kasani, A., Hall, E., Subedi, R., Rahim, M., Maiti, S. BIOORG.MED.CHEM.LETT.