CATH Domain 2fxfA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.630	Aminopeptidase
	3.40.630.30	Gcn5-related N-acetyltransferase (GNAT)

Domain Context

CATH Clusters

Superfamily	3.40.630.30
Functional Family	Diamine acetyltransferase 1

Enzyme Information

2.3.1.57

Diamine N-acetyltransferase.

based on mapping to UniProt P21673

Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.

-!- Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)- acetylspermidine and N(8)-acetylspermidine.

UniProtKB Entries (1)

P21673

SAT1_HUMAN

Homo sapiens

Diamine acetyltransferase 1

PDB Structure

PDB	2FXF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The Crystal Structure of Human spermidine/spermine N1-acetyltransferase Min, J.R., Wu, H., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N. To be Published