CATH Domain 2fvzA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.190	D-Maltodextrin-Binding Protein; domain 2
	3.40.190.80

Domain Context

CATH Clusters

Superfamily	3.40.190.80
Functional Family	Inositol-1-monophosphatase

Enzyme Information

3.1.3.25

Inositol-phosphate phosphatase.

based on mapping to UniProt O14732

Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.

-!- Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. -!- It also acts on adenosine 2'-phosphate (but not the 3'- or 5'-phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate, but does not act on inositol bisphosphates or more phosphorylated inositols.

UniProtKB Entries (1)

O14732

IMPA2_HUMAN

Homo sapiens

Inositol monophosphatase 2

PDB Structure

PDB	2FVZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of Human Inositol Monophosphatase 2 Thorsell, A.G., Ogg, D., Berglund, H., Collins, R., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Hogbom, M., Holmberg-Schiavone, L., Kotenyova, T., Kursula, P., Nilsson-Ehle, P., Persson, C., Nordlund, P., Nyman, T., Sagemark, J., Stenmark, P., Van Den Berg, S., Weigelt, J., Hallberg, B.M. To be published