CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.50 | Alpha/alpha barrel |
|
1.50.10 | Glycosyltransferase |
|
1.50.10.100 | Chondroitin AC/alginate lyase |
Domain Context
CATH Clusters
| Superfamily | Chondroitin AC/alginate lyase |
| Functional Family |
Enzyme Information
| 4.2.2.8 |
Heparin-sulfate lyase.
based on mapping to UniProt C6XZB6
Elimination of sulfate, appears to act on linkages between N-acetyl-D- glucosamine and uronate. Product is an unsaturated sugar.
-!- Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.
|
| 4.2.2.7 |
Heparin lyase.
based on mapping to UniProt C6XZB6
Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non- reducing ends.
|
UniProtKB Entries (1)
| C6XZB6 |
HEPB_PEDHD
Pedobacter heparinus DSM 2366
Heparin and heparin-sulfate lyase
|
PDB Structure
| PDB | 2FUT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure of Heparinase II from Pedobacter heparinus and Its Complex with a Disaccharide Product.
J.Biol.Chem.
|
