CATH Domain 2frvD00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.645	Cytochrome-c3 Hydrogenase; chain B
	1.10.645.10	Cytochrome-c3 Hydrogenase, chain B

Domain Context

CATH Clusters

Superfamily	Cytochrome-c3 Hydrogenase, chain B
Functional Family	Hydrogenase 2 large subunit

Enzyme Information

1.12.2.1

Cytochrome-c3 hydrogenase.

based on mapping to UniProt P12944

H(2) + 2 ferricytochrome c3 = 2 H(+) + 2 ferrocytochrome c3.

-!- Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases). -!- Methylene blue and other acceptors can also be reduced.

UniProtKB Entries (1)

P12944

PHNL_DESGI

Desulfovibrio gigas

Periplasmic [NiFe] hydrogenase large subunit

PDB Structure

PDB	2FRV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of the [Nife] Hydrogenase Active Site: Evidence for Biologically Uncommon Fe Ligands Volbeda, A., Garcin, E., Piras, C., De Lacey, A.L., Fernandez, V.M., Hatchikian, E.C., Frey, M., Fontecilla-Camps, J.C. J.Am.Chem.Soc.