CATH Domain 2fpoA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family

Enzyme Information

2.1.1.171

16S rRNA (guanine(966)-N(2))-methyltransferase.

based on mapping to UniProt P0ADX9

S-adenosyl-L-methionine + guanine(966) in 16S rRNA = S-adenosyl-L- homocysteine + N(2)-methylguanine(966) in 16S rRNA.

-!- The enzyme efficiently methylates guanine(966) of the assembled 30S subunits in vitro. -!- Protein-free 16S rRNA is not a substrate for RsmD. -!- The enzyme specifically methylates guanine(966) at N(2) in 16S rRNA. -!- Formerly EC 2.1.1.52.

UniProtKB Entries (1)

P0ADX9

RSMD_ECOLI

Escherichia coli K-12

Ribosomal RNA small subunit methyltransferase D

PDB Structure

PDB	2FPO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure. Lesnyak, D.V., Osipiuk, J., Skarina, T., Sergiev, P.V., Bogdanov, A.A., Edwards, A., Savchenko, A., Joachimiak, A., Dontsova, O.A. J.Biol.Chem.