CATH Domain 2fn6A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1150	Aspartate Aminotransferase, domain 1
	3.90.1150.10	Aspartate Aminotransferase, domain 1

Domain Context

CATH Clusters

Superfamily	Aspartate Aminotransferase, domain 1
Functional Family	UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase

Enzyme Information

2.6.1.92

UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase.

based on mapping to UniProt O25130

UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate.

-!- The enzyme transfers the primary amino group of L-glutamate to C-4'' of UDP-4-dehydro sugars, forming a C-N bond in a stereo configuration opposite to that of UDP. -!- The enzyme from the bacterium Bacillus cereus has been shown to act on UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose, UDP-beta- L-threo-pentapyranos-4-ulose, UDP-4-dehydro-6-deoxy-D-glucose, and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose. -!- Cf. EC 2.6.1.34, which catalyzes a similar reaction, but forms the C-N bond in the same stereo configuration as that of UDP.

UniProtKB Entries (1)

O25130

PSEC_HELPY

Helicobacter pylori 26695

UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase

PDB Structure

PDB	2FN6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural and Functional Characterization of PseC, an Aminotransferase Involved in the Biosynthesis of Pseudaminic Acid, an Essential Flagellar Modification in Helicobacter pylori Schoenhofen, I.C., Lunin, V.V., Julien, J.P., Li, Y., Ajamian, E., Matte, A., Cygler, M., Brisson, J.R., Aubry, A., Logan, S.M., Bhatia, S., Wakarchuk, W.W., Young, N.M. J.Biol.Chem.