CATH Domain 2fjpA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.140	8 Propeller
	2.140.10	Methanol Dehydrogenase; Chain A
	2.140.10.30	Dipeptidylpeptidase IV, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Dipeptidylpeptidase IV, N-terminal domain
Functional Family	Dipeptidyl peptidase 4

Enzyme Information

3.4.14.5

Dipeptidyl-peptidase IV.

based on mapping to UniProt P27487

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (1)

P27487

DPP4_HUMAN

Homo sapiens

Dipeptidyl peptidase 4

PDB Structure

PDB	2FJP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Edmondson, S.D., Mastracchio, A., Mathvink, R.J., He, J., Harper, B., Park, Y.J., Beconi, M., Di Salvo, J., Eiermann, G.J., He, H., Leiting, B., Leone, J.F., Levorse, D.A., Lyons, K., Patel, R.A., Patel, S.B., Petrov, A., Scapin, G., Shang, J., Roy, R.S., Smith, A., Wu, J.K., Xu, S., Zhu, B., Thornberry, N.A., Weber, A.E. J.Med.Chem.