CATH Classification

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family

Enzyme Information

3.1.4.11
Phosphoinositide phospholipase C.
based on mapping to UniProt P10686
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (1)

P10686
PLCG1_RAT
Rattus norvegicus
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

PDB Structure

PDB 2FJL
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Structural Characterization of the Split Pleckstrin Homology Domain in Phospholipase C-{gamma}1 and Its Interaction with TRPC3
Wen, W., Yan, J., Zhang, M.
J.Biol.Chem.