CATH Domain 2fbwB02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1060	Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
	1.10.1060.10	Alpha-helical ferredoxin

Domain Context

CATH Clusters

Superfamily	Alpha-helical ferredoxin
Functional Family	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Enzyme Information

1.3.5.1

Succinate dehydrogenase (quinone).

based on mapping to UniProt Q9YHT2

Succinate + a quinone = fumarate + a quinol.

-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

Q9YHT2

SDHB_CHICK

Gallus gallus

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

PDB Structure

PDB	2FBW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. Huang, L.S., Sun, G., Cobessi, D., Wang, A.C., Shen, J.T., Tung, E.Y., Anderson, V.E., Berry, E.A. J.Biol.Chem.