CATH Classification
Level | CATH Code | Description |
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4 | Few Secondary Structures | |
4.10 | Irregular | |
4.10.80 | Rhinovirus 14, subunit 4 | |
4.10.80.40 | succinate dehydrogenase protein domain |
Domain Context
CATH Clusters
Superfamily | succinate dehydrogenase protein domain |
Functional Family | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
Enzyme Information
1.3.5.1 |
Succinate dehydrogenase (quinone).
based on mapping to UniProt Q9YHT1
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.
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UniProtKB Entries (1)
Q9YHT2 |
SDHB_CHICK
Gallus gallus
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
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PDB Structure
PDB | 2FBW |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.
J.Biol.Chem.
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