CATH Domain 2f7dA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38

Cathepsin K.

based on mapping to UniProt P43236

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43236

CATK_RABIT

Oryctolagus cuniculus

Cathepsin K

PDB Structure

PDB	2F7D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Pichia
Primary Citation	Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K. Crane, S.N., Black, W.C., Palmer, J.T., Davis, D.E., Setti, E., Robichaud, J., Paquet, J., Oballa, R.M., Bayly, C.I., McKay, D.J., Somoza, J.R., Chauret, N., Seto, C., Scheigetz, J., Wesolowski, G., Masse, F., Desmarais, S., Ouellet, M. J.Med.Chem.